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Injectarea trebuie făcută în submucoasă, fără a depăşi musculara propria pentru că altfel colorantul se poate împrăştia în peritoneu. Pentru a evita injectarea transmurală se poate folosi, înainte de injectarea colorantului, o soluţie salină pentru formarea papulei şi apoi injectarea de agent de tatuaj.

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