Metastatic cancer bone. Traducere "metastaze osoase" în engleză How Cancer Spreads Metastasis - Michael Henry, PhD Rezumat: Bisphosphonates are effective against the increased bone resorption caused by certain diseases because they inhibit the activity of osteoclasts.
In patients who have breast cancer and metastatic bone disease, the bisphosphonate clodronate clodronic acid reduces the frequency of skeletal complications. Experiments in animals and preliminary clinical observations indicate that early clodronate therapy reduces the incidence of new bony metastases in breast cancer.
Bone Cancer, Primary Bone Cancers and Bone Metastases
We investigated the effects of clodronate on the incidence and extent of new metastases in patients with breast cancer.
METHODS: Between andpatients with primary breast cancer and metastatic cancer bone cells in the bone marrow the presence of which is a risk factor for the development of metastatic cancer bone metastases were randomly assigned to receive clodronate at a metastatic cancer bone of mg per day orally for two years patients or metastatic cancer bone follow-up patients.
The median length of observation was 36 months. All patients in both groups received standard surgical treatment and customary hormonal therapy or chemotherapy. RESULTS: Distant metastases were detected in 21 patients in the clodronate group and in 42 patients in the control group P Cuvinte cheie: breast cancer, bisphosphonates, adjuvant, clinical trial, clodronate.